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KMID : 1101320110430010012
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Korean Journal of Clinical Laboratory Science
2011 Volume.43 No. 1 p.12 ~ p.18
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Correlation Study Between Anemias with Higher MCV and Lower MCHC
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Choi Woo-Soon
Kim Hee-Sang
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Abstract
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The purpose of this study was to evaluate the significance of higher than normal mean corpuscular volume (MCV) and lower than normal mean corpuscular hemoglobin concentration (MCHC) in 20 patients. The hemoglobin (Hb), red blood cell indices (MCV, MCH, MCHC,), red cell distribution width (RDW), serum ferritin, serum iron (Fe) and total iron binding capacity (TIBC) were measured and the transferrin saturation were calculated. 18 (90.0%) cases were categorized as chronic diseases. Chronic renal failure, malignancy, and bleeding were all related to the cases. The mean values of hemoglobin was 9.5±2.14 g/dL; the MCV was 29.0±2.8 fL; the MCH was 30.9±1.0 pg; the MCHC was 31.2±0.5％; the RDW was 17.0±3.6％; serum Fe was 39±21 μg/dL; the TIBC was 219.7±108.8 μg/dL; transferrin saturation was 19.2±9.9％ and ferritin was 445.5±499.6 μg/L in the patients. The WHO criteria for hemoglobin of patients confirms anemia in 18 of the 20 (90.0%) cases. Anemia of chronic disease was shown in 11 (73.3%) cases; acute gastric ulcer with hemorrhage in 1 (6.7%) case; iron deficiency anemia in 1 (6.7%) case; 2 patients (13.3%) were of normal cases . There were changes in the baseline Hb level results of the 19 (95.0%) cases while no change was shown in 1 case. As a result, diseases associated with anemia and bleeding where the MCV is higher than the normal range and MCHC is lower than normal range are considered relevant findings.
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KEYWORD
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Anemia, MCV, MCHC, Hemoglobin, Bleeding
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